Scientific Programme
last update: 2018-09-18

Tuesday, 18th September 2018
15.00-17.30
Meeting of the Board of Polish Biochemical Society

Place: D209
18.00-19.30
Opening ceremony
Opening Lectures


Place: S204/205
18.30-19.00
PL.1. Ted Hupp
University of Edinburgh, Scotland, International Centre for Cancer Vaccine Science Gdańsk

Interferon responsive genes that link adaptive and innate immunity in human cancer


Place: S204/205
19.00-19.30
PL.2. Robin Fahraeus
Paris Diderot University, France, International Centre for Cancer Vaccine Science Gdańsk

Viral mRNA translation control: linking immune evasion with oncogenesis


Place: S204/205
19.30
Welcome Party

Place: Upper level of the Faculty of Social Sciences University of Gdańsk

Wednesday, 19th September 2018
Plenary Lecture
Morning sessions
9.00-9.45
PL.3. Marek Figlerowicz
Institute of Bioorganic Chemistry PAS, Poznań, Poland

Genomics in uncovering our history


Place: S205
Session line
DNA World
RNA World
EMBO
Polish Society for Cell Biology
session 1

Place: S204
session 2

Place: S205
session 3

Place: S207
session 4

Place: S208
Morning sessions
9.45-13.15
Marek Figlerowicz
IBCh PAS, Poland
Tomasz Żemojtel
Berlin Inst. of Health, Germany

Genomics and genomics-driven research
Andrzej Dziembowski
IBB & UW, Poland

RNA and RNP structures and mechanisms of action: from theory to experiment

Krzysztof Liberek
IFB UG&MUG, Gdańsk, Poland
Joanna Sułkowska
CENT Poland

EMBO Session

Halina Gabryś
UJ, Cracow, Poland

Signaling in plant cells

Lectures:Lectures:Lectures:Lectures:
09.45-09.50
IBCh PAS, Poland
Tomasz Żemojtel
Berlin Inst. of Health, Germany

Short introduction
L.2.1. Marcin Nowotny
IIMCB, Warsaw, Poland

Structural and biochemical studies of the yeast mitochondrial RNA degradosome
Krzysztof Liberek
IFB UG&MUG, Gdańsk, Poland

Introduction
L.4.1. Ute Vothknecht
Univ. of Bonn, Germany

Calcium Regulation of Plant Organellar Metabolism

09.50-10.00
L.3.1. Magda Konarska
CENT, Warsaw, Poland, new EMBO member

Dynamic rearrangements of the spliceosomal catalytic center
10.00-10.15
L.1.1. Izabela Makałowska
UAM, Poznań, Poland

Activity of retroposed genes in tumors
10.15-10.30
L.2.2. Jacek Jemielity
CENT, Warsaw, Poland

Chemically modified mRNA
L.3.2. Joanna Sułkowska
CENTR, Warsaw, Poland
EMBO Young Investigator

Mysteries of entanglement – from a single protein to a pair of chromosomes

L.4.2. Axel Mithofer
Max-Planck-Inst. for Chemical Ecology, Jena, Germany

Plant Calcium Signaling in biotic Interactions

10.30-10.35
10.35-10.40
L.1.2. Tomasz Żemojtel
Berlin Inst. of Health, Germany

Liquid biopsy: challanges and opportunities
10.40-10.45
L.3.3. Piotr Ziółkowski
UAM, Poznań, Poland
EMBO Installation Ggrantee

Control of meiotic recombination: from chromosomal distribution to crossover frequency
10.45-11.05
L.2.3. Maciej Kozak
UAM, Poznań, Poland

Applications of small-angle X-ray and neutron scattering (SAXS/SANS) in studies of complexes and flexible protein structures
L.4.3. Halina Gabryś
UJ, Cracow, Poland

Calcium and magnesium in blue light signaling in the mesophyll cell

11.05-11.10
Break
11.10-11.15
Break
11.15-11.35
Break
11.35-11.40
Break
L.3.4. Marta Miączyńska
IIMCB, Warsaw, Poland
new EMBO member

Inflammatory signaling from the endocytic pathway

Break
11.40-11.45
L.1.3. Agnieszka Żmieńko

AthCNV - a map of DNA copy number variations in Arabidopsis thaliana genome based on the 1001 Genomes Project data
Break
11.45-12.00
L.2.4. Krzysztof Ginalski
CENT, Warsaw, Poland

Identification and classification of proteins involved in nucleic acids metabolism
L.4.4. Dorota Konopka-Postupolska
IBB, Warsaw, Poland

The role of calcium in cellular membrane flow
12.00-12.15
L.3.5. Maria Górna
UW, Warsaw, Poland
EMBO Installation Grantee

Installation Grantee
How to end a viral RNA- lessons from the IFIT proteins
12.15-12.25
O.1.1. Małgorzata Marcinkowska-Swojak

Half the costs keep the quality. Targeted enrichment for the Next Generation Sequencing of ancient genomes
L.2.5. Andrzej Dziembowski
CENTIBB & UW, Warsaw, Poland

Regulation of gene expression by non-canonical poly(A) and poly(U) polymerases
O.4.1.Małgorzata Pietrowska-Borek

Is RAB GTPase homolog E1B (RABE1b) involved in response to cadmium stress in Arabidopsis thaliana seedlings by cGMP synthesis?
12.25-12.30
L.3.6. Wojciech Pokrzywa
IIMCB, Warsaw, Poland
EMBO Installation grantee

Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
12.30-12.45
O.1.2. Patrycja Jakubek

Catechins as modulators of DNA methylation
O.4.2. Weronika Krzeszowiec-Jeleń

Exogenous amino acids affect the image of actin cytoskeleton in Arabidopsis mesophyll cells
12.45-12.50
O.1.3. Sabina Żołędowska

Investigating the pangenome of the plant pathogenic Pectobacterium parmentieri provides insight into its outstanding adaptation abilities
O.2.1. Roman Szczęsny

The mitochondrial degradosome complex and its co-factors prevent accumulation of double-stranded RNA in humans
12.50-13.00
L.3.7. Agata L. Starosta

Undercover translation. Hidden secrets of the ribosome
13.00-13.15
O.1.4. Agata Motyka

Closure of the Dickeya solani pangenome
O.2.2. Michał Wojciech Szcześniak

Long non-coding RNAs as modulators of
splicing in trans via direct RNA:RNA interactions
13.30-14.15
Lunch
and
Poster session: P1-P8

Poster sessions list
14.30-15.15
PL.4. Bożena Kamińska-Kaczmarek
Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

Immune microenvironment of glioma

Lecture sponsored by Nencki Inst. of Experimental Biology PAS, Warsaw, Poland- 100 years anniversary of the Nencki Inst. of Experimental Biology PAS


Place: S205
Session line
New molecular targets / World of application
RNA World
Protein World
Session sponsored by COST Action CA16112 "NutRedOx"
session 5

Place: S204
session 6

Place: S205
session 7

Place: S207
session 8

Place: S208
session 30

Place: S211
Afternoon sessions
15.15-16.45
Krystyna Bieńkowska-Szewczyk
IFB UG&MUG, Gdańsk, Poland
Bogusław Szewczyk
UG&MUG

Molecular virology
Zofia Szweykowska-Kulińska
UAM, Poznań, Poland
Piotr Kozłowski
IBCh PAS, Poznań, Poland


Non-coding RNA and gene expression

Marcin Nowotny
IIMCB, Warsaw, Poland
Alessandro Costa
The Francis Crick Inst., London, UK

Structural studies of large assemblie


Adam Szewczyk
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland
Wiesława Jarmuszkiewicz
UAM, Poznań, Poland

Molecular bioenergetics
Caroline Gaucher
University of Lorraine, Nancy, France
Jędrzej Antosiewicz
MUG, Gdańsk, Poland

Redox control of major age-related diseases
Lectures:Lectures:Lectures:Lectures:Lectures:
15.15-15.25
L.5.1. Timm C. Harder
FLI, Riems, Germany

100 years from Spanish flu- can we control influenza today?
Zofia Szweykowska-Kulińska
UAM, Poznań, Poland
Piotr Kozłowski
IBCh PAS, Poznań, Poland
Marek Figlerowicz
Institute of Bioorganic Chemistry PAS, Poznań, Poland

Introduction

In memory of Professor Włodzimierz Krzyżosiak
L.7.1. Wojciech Galej
EMBL, Grenoble, France

Structure and dynamics of the spliceosome
L.8.1. Wiesława Jarmuszkiewicz
UAM, Poland

Impact of temperature and training on skeletal muscle bioenergetics

L.30.1. Marc Diederich
Seoul National University, Korea

About canonical and less canonical cell death induction by natural compounds with pharmacological potential
15.25-15.45
L.6.1. Zofia Szweykowska-Kulińska
UAM, Poland

Biogenesis and function of plant microRNAs
15.45-16.05
L.5.2. Arvind H. Patel
MRC-University of Glasgow Centre for Virus Research, UK

Conformational flexibility in the receptor-binding
site of the Hepatitis C Virus Glycoprotein E2

100 years from Spanish flu- can we control influenza today?
L.6.2. Piotr Kozłowski
IBCh PAS, Poznań, Poland

Copy number variation and other types of genetic alterations in miRNA genes and their potential implications for miRNA function and human diseases
L.7.2. Alessandro Costa
The Francis Crick Institute, London, UK

Eukaryotic replisome assembly and fork progression visualized by cryo-EM
L.8.2. Wiesław Gruszecki
UMCS, Lublin, Poland

Warming-up of the chloroplast

L.30.2. Marek Naruszewicz
Medical University of Warsaw, Poland

Oleacein, translation from Mediterranean diet to preventive medicine
16.05-16.15
O.6.1. Susheel Sagar Bhat

Arabidopsis thaliana mRNA adenosine methylase (MTA) is an important player in miRNA biogenesis regulatory pathway
16.15-16.25
L.5.3. Alicja Chmielewska

Adenovirus vectors for genetic vaccination and oncolytic virotherapy
O.6.2. Anna Kurzyńska-Kokorniak

A possible direct involvement of Dicer ribonuclease in the post-transcriptional control of gene expression
L.7.3.Michał Szymański
IFB UG & GUMed, Gdańsk, Poland

Structure and function of macromolecular machines
L.8.3. Adam Szewczyk
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland

Mitochondrial regulation of mitochondrial potassium channels

L.30.3. Tomris Ozben

Natural redox modulators of oxidative stress and chemoresistance in cancer therapy: beneficial versus deleterious effects
16.25-16.35
O.6.3. Joanna Boguslawska

TGF-β1 affects proliferation, viability and migration of renal cancer cells, possibly by targeting regulatory microRNAs
16.35-16.45
O.6.4. Ankur Gadgil

U7 snRNA activity and histone gene expression is affected by ALS-linked FUS mutations
16.45-17.00
BreakBreak
17.00-18.00
Sponsored session

Place: S205
O.8.1. Bogusz Kulawiak

Single-channel properties of the ROMK2-pore-forming subunit of the mitochondrial ATP-regulated potassium channel

17.00-17.15
Merck sponsored session

Immunophenotyping Extracellular Vesicles using innovative flow cytometry
17.15-17.30
O.7.1. Michał Gabruk

Towards the near-atomic resolution structure of light-dependent protochlorophyllide oxidoreductase
O.8.2. Andonis Karachitos

Evaluation of mitochondrial energetic status and oxidative stress during tardigrade anhydrobiosis
17.30-17.45
O.8.3. Karol Parchem

Dietary oxidized phospholipids: digestion, absorption and metabolism
17.45-17.55
O.8.4. Karolina Dominiak

Coenzyme Q and ROS production in mitochondria
17.55-18.00
18.00-19.30
General assembly of the Polish Biochemical Society

Place: S205

Thursday, 20th September 2018
Plenary Lecture
Morning session
9.00-9.45
PL.5. Peter Mackenzie
Flinders University, Adelaide, Australia
The UDP glycosyltransferase superfamily: its role in signal transduction termination and protection against chemical toxicity

Lecture sponsored by the Rector of the Gdańsk University of Technology


Place: S205
Session line
Metabolite World
Cell & Organ World
DNA World
Sesion sponsored by COST Action CA16112 "NutRedOx"
9.45-11.15
session 9

Place: S204
session 10

Place: S205
session 11 - part I

Place: S207
session 12

Place: S208
session 30 part II

Place: S211
Władysława A. Daniel
PAS, Poland
Krzysztof Safranow
PUM, Szczecin, Poland

The physiological and pharmacological regulation of endobiotic and drug metabolizing enzymes

Ryszard T. Smoleński
MUG, Gdańsk, Poland
Stefan Chłopicki
UJ, Cracow, Poland

Endothelial dysfunction and atherosclerosis
Agnieszka Łoboda
UJ, Cracow, Poland
Robert Passier
University of Twente, Enschede, The Netherlands

Medical biotechnology in regenerative medicine and drug research

Session sponsored by STARBIOS 2 Structural Transformation to Attain Responsible BIOSciences EU FP Horizon 2020
Jarosław Marszałek
IFB UG&MUG, Gdańsk, Poland
Ryszard Korona
UJ, Cracow, Poland

Evolutionary biochemistry
Agnieszka Bartoszek
Gdańsk University of Technology, Gdańsk
Mustafa C. Malki
Université de Bourgogne, Dijon, France

Redox control of major age-related diseases
Lectures:Lectures:Lectures:Lectures:Lectures:
09.45-10.15
L.9.1. Władysława A. Daniel
PAS, Poland

The regulation of liver cytochrome P450 by the brain nervous system

L.10.1. Ryszard T. Smoleński
MUG, Gdańsk, Poland

Energetics of cardiac myocyte in atherosclerosis
L.11.1. Graziella Pellegrini
Univ. of Modena, Italy

Epithelial stem cells, a real tool for effective regenerative medicine treatments

L.12.1. Grzegorz Kudła
Univ. of Edinburgh, UK

Next generation genotype-phenotype mapping
L.30.4. Linda Giblin

Whey Protein: can it boost cellular antioxidant processes?

10.15-10.45
L.9.2. Krzysztof Safranow
PUM, Szczecin, Poland

Consequences of muscle AMP deaminase deficiency caused by common nonsense mutation In AMPD1 gene – a new look at the role of purine nucleotide cycle

L.10.2. Stefan Chłopicki
UJ, Cracow, Poland

Endothelial profiling in vivo: novel approach to experimental pharmacology of endothelium
L.11.2. Józef Dulak
UJ, Cracow, Poland

Targeting inflammation for treatment of Duchenne muscular dystrophy

L.12.2. Kataryna Tomala
UJ, Cracow, Poland

Searching for factors underlaying slower evolution of abundant proteins
L.30.5. Jarosław Paluszczak

Modulation of Wnt signaling by natural and synthetic compounds in cancer cells
10.45-11.00
O.9.1. Agnieszka Potęga

Electrochemistry/liquid chromatography/mass spectrometry for the simulation of in vitro metabolism of unsymmetrical bis-acridines with antitumor properties

O.10.1. Alicja Bulińska

Nucleotide and adenosine converting ecto-enzyme pattern in endothelial activation and vascular inflammation

O.11.1. Krzysztof Kobielak

Regulation of hair follicle stem cells homeostasis by activation of gene inhibitory network

L.12.3. Ryszard Korona
UJ, Cracow, Poland

The paradox of dominance: halving the dose of a gene leaves its function unaffected (usually)
11.00-11.15
O.10.2. Armen Trchounian

Antioxidant activity of alcohol extracts from some plants of Armenian flora: the highest level and its possible nature

O.11.2. Jacek Stępniewski

Administration of HO-1/SDF-1α-overexpressing mesenchymal stromal cells in murine and swine model of myocardial infarction and heart failure – analysis of therapeutic effect

11.15-11.45
Break
Session line
Metabolite World
Cell & Organ World
New molecular targets / World of application
11.45-13.15
session 13

Place: S204
session 14

Place: S205
session 11 - part II

Place: S207
session 15

Place: S208
Wanda Baer-Dubowska
PUMS, Poland
Gniewomir Latacz
UJ, Cracow, Poland

Metabolic activation of xenobiotics - therapeutic target and drug monitoring
Anna Ronowska
Medical University of Gdańsk, Poland
Andrzej Szutowicz
Medical University of Gdańsk, Poland

New biomarkers in neurodegenerative diseases
Józef Dulak
UJ, Cracow, Poland
Graziella Pellegrini
University of Modena, Modena, Italy

Medical biotechnology in regenerative medicine and drug research

Session sponsored by STARBIOS 2 Structural Transformation to Attain Responsible BIOSciences EU FP Horizon 2020
Tomasz Wilanowski
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland
Anna Radominska-Pandya
University of Arkansas of Medical Sciences , USA

New molecular targets in personalized therapy of cancer

Lectures:Lectures:Lectures:Lectures:
11.45-12.15
L.13.1. Uwe Sauer
Inst. of Molecular Systems Biology, Switzerland

Metabolic coordination through metabolite-protein interactions

L14.1. Monika Szeliga-Mossakowski
Medical Research Centre PAS, Warsaw, Poland

Astroglia in health and pathology

L.11.3. Robert Passier
Univ. of Twente, The Netherlands

Human pluripotent stem cell-derived cardiac cells for disease modeling, drug screening and regenerative medicine

L.15.1. Tomas Wilanowski
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland

Grainyhead-like transcription factors as targets of anti-cancer therapy
12.15-12.45
L.13.2. Hanna Piotrowska-Kempisty
PUMS, Poland

The metabolic activation of methylated resveratrol analogue 3,4,4’,5-tetra-methoxystilbene (DMU-212) to 3’hydroxy-3,4,4,4’-tetramethoxystilbene (DMU-214)
L.14.2. Andrzej Szutowicz
MUG, Gdańsk, Poland

Regulatory effects of acetyl-CoA distribution in cellular compartments of healthy and diseased brain

L.11.4. Agnieszka Łoboda
UJ, Cracow, Poland

HO-1 as a possible drug target

L.15.2. Anna Radominska-Pandya
UAMS, USA

Natural Compounds Activating Cannabinoid Receptors CB1 and CB2: future for the cancer treatments
12.45-12.55
O.13.1. Mikhail Kurbat

Hyperhomocysteinemia caused by highly active antiretroviral therapy (HAART) of HIV infection: focus on mitochondria

O.14.1. Anna Ronowska

Thiamine deficits aggravate zinc cytotoxicity in cholinergic SN56 neuronal cells

O.11.3. Katarzyna Kaławaj

Alpha-ketoglutarate (AKG) induces apoptosis in osteosarcoma cells in vitro through the activation of JNK MAP kinase

O.15.1. Małgorzata Rogalińska

The importance of drug type and dose on CLL cells in vitro sensitivity to anticancer-agents

12.55-13.00
O.15.2. Łukasz Skalniak

Novel strategies of PD-1/PD-L1 immune checkpoint blockade for cancer therapy: antibodies, peptides and small molecule

13.00-13.05
O.13.2. Annamaria Lubelska

Metabolic stability as a challenge in the early stage of drug discovery process – in vitro determination of metabolic pathways for new promising 5-HT7R ligands

O.11.4. Izabela Sadowska-Bartosz

3-Bromopyruvic acid: a small molecule with strong anti-tumor potency

13.05-13.15
O.15.3. Błażej Rubiś

Telomerase targeting modulates cancer response to therapy

13.30-14.15
Lunch
and
Poster session: P11-P19

Poster sessions list
14.30-15.15
PL.6. Narayanan Veeraraghavan
Rady Children’s Hospital-San Diego, USA

Clinical Utility of Rapid Whole Genome Sequencing in pediatric critical care

Lecture sponsored by Rector of the Medical University of Gdańsk


Place: S205
Session line
Metabolite World
Cell & Organ World
New molecular targets / World of application
Satellite session: Women in Science
15.15-16.45
session 16

Place: S204
session 17

Place: S205
session 18

Place: S207
session 19

Place: S208
Satellite session 1

Place: S211
Micał Markuszewski
MUG, Gdańsk, Poland
Micał Ciborowski
Medical University of Bialystok

Clinical metabolomics
Rafał Sądej
IFB UG&MUG, Poland
Anna Żaczek
IFB UG&MUG, Poland

Tumor microenvironment in cancer progression
Piotr Trzonkowski
MUG, Poland
Ewa M. Martinez-Caceres
Generalitat de Catalunya, Spain

New molecular targets
in personalized therapy of autoimmune diseases

Session sponsoring by - COST project - Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies BM1305, EU FP Horizon 2020.
Hanna Jańska
UWr, Wrocław, Poland
Agnieszka Mostowska
UW, Warsaw, Poland

Inside plant organelles: structure, function and stress response
Session sponsored by L’Oreal Poland

Chairwoman - Agnieszka Chacińska
Centre of New Technologies University of Warsaw, Poland
Lectures:Lectures: Lectures:Lectures:Lectures:
15.15-15.45
L.16.1. Danuta Dudzik
San Pablo CEU University, Madrid, Spain

Metabolomics meets clinics - application to maternal-fetal and neonatal medicine
L.17.1. Przemysław Juszczyński
IHiTM, Poland
Tumor suppressor function of FOXO1 in diffuse large B-cell lymphomas: mechanisms of regulation and rational targeting strategies
Parnas Memory Lecture

L.18.1. Ewa M. Martinez-Caceres
Generalitat de Catalunya, Spain

Tolerance-induction with autologous tolerogenic dendritic cells treated with VITamin D3 and loaded with myelin peptides in MultiPe Sclerosis (Tolervit-MS)
L.19.1. Oliver van Aken
Lund Univ., Sweden

Exploring organelle-to-nuclear signaling during plant stress responses.

Annie Black
Deputy Executive Director L'Oréal Corporate Foundation, France Introduction


Agnieszka Chacińska
Centre of New Technologies University of Warsaw, Poland


Panelists:

Bożena Kamińska
Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

Agata Starosta
Maria Curie Skłodowska University in Lublin, Poland

Joanna Sułkowska
Centre of New Technologies University of Warsaw, Poland

Zofia Szweykowska-Kulińska
Adam Mickiewicz University Poznań, Poland
15.45-16.15
L.16.2. Michał Ciborowski
Medical University of Bialystok, Poland

Metabolomics in the clinical settings. Applications in diabetology and endocrinology

L.17.2. Katarzyna Miękus
UJ, Cracow, Poland

Role of anti-inflammatory protein MCPIP1 in clear cell renal cell carcinoma progression

L.18.2. Piotr Trzonkowski
MUG, Gdańsk, Poland

T-regulatory cells to treat autoimmune diseases
L.19.2. Łucja Kowalewska
UW, Warsaw, Poland

Structural plasticity of the chloroplast thylakoid network.

16.15-16.45
L.17.3. Rafał Sądej
IFB UG&MUG, Gdańsk, Poland

Tumour microenvironment in luminal breast cancer progression
L.19.3. Małgorzata Heidorn-Czarna
UW, Warsaw, Poland

Functional relevance of mitoproteases in plant mitochondria.

16.45-17.00
Break
17.00-18.30
session 20

Place: S204
session 17 continued

Place: S205
session 21

Place: S207
session 22

Place: S208
Ewa Świeżewska
IBB, Warsaw, Poland
Anna Ihnatowicz
IFB UG&MUG, Gdańsk, Poland

Plant biochemistry and metabolomics

Rafał Sądej
IFB UG&MUG, Poland
Anna Żaczek
IFB UG&MUG, Poland

Tumor microenvironment in cancer progression
Marta Olejniczak
IBCh PAS, Poznań, Poland
Krzysztof Chyliński
CRISPR Lab, Wien, Austria

CRISPR technologies for targeted genome editing
Dariusz Rakus
UWr, Wrocław, Poland
Jacek R. Wiśniewski
MPI Biochemie, Germany

Proteomics of ageing and diseases
Lectures:Oral presentationsLectures:Lectures:
17.00-17.20
L.20.1. Asaph Aharoni
Weizmann Inst., Israel

Plant ‘Metabolic Caravans’: from anti-nutritional to anti-Parkinson alkaloids

O.17.1. Halina Waś

Chemotherapeutics-treated cancer cells display stem-like and senescent cell feature

L.21.1. Krzysztof Chyliński
CRISPR Lab Vienna, Austria

Temporal control of CRISPR/Cas9 activity
L.22.1. Jacek R. Wiśniewski
MPI Biochemie, Germany

Large scale proteomics for studying physiology and disease

17.20-17.30
17.30-17.40
L.20.2. Anna Ihnatowicz
IFB UG&MUG, Gdańsk, Poland

Genetic regulation of isoprenoid accumulation in plants – what have we learned from analysis of biochemical and genetic data?

L.21.2. Marta Olejniczak
IBCh PAS, Poznań, Poland

Evaluation of CRISPR/Cas9-mediated genome editing efficiency
L.22.2. Aneta Stachowicz

Proteomics of plasma fibrin clot in antiphospholipid syndrome

17.40-17.55
O.17.2. Natalia Bednarz-Knoll

Preoperative high platelets counts and low hemoglobin correlate to mesenchymal phenotype of circulating tumor cells and worse clinical outcome in human breast carcinoma

17.55-18.00
O.17.3. Aleksandra Solecka

The influence of metabolism on the phenotype of astrocytoma U-251 MG cell line

18.00-18.10
O.20.1. Joanna Grzyb

Bionanohybrids between phycobilisomes and colloidal quantum dots – studies of energy transfer in complicated systems

L.22.3. Dariusz Rakus
UWr, Wrocław, Poland

Aging-associated changes in hippocampal glycogen metabolism. Evidence for and against astrocyte-neuron lactate shuttle

18.10-18.15
O.17.4. Izabela Papiewska-Pająk

Extracellular vesicles secreted by colorectal cancer cell line HT29 overexpressing Snail can fuse with and activate the cells constituting metastatic niche

18.15-18.25
O.20.2. Katarzyna Jasieniecka-Gazarkiewicz

Acyl-CoA:lysophosphatidylethanolamine acyltransferase (LPEAT) activity regulates plant growth and autophagy level

18.25-18.30
O.17.5. Magdalena Mizerska-Kowalska

Tumor-associated neutral endopeptidase (tNEP) regulates cell proliferation and TGF-β production in cultures and co-cultures of colon cancer cells with colon fibroblasts

18.30-18.40
20.00
Gala Dinner including complimentary lecture

Place: UNICORN Restaurant

Friday, 21st September 2018
Plenary lecture
9.00-9.45
PL.7. Magdalena Król
SGGW, Warsaw, Poland

The macrophage-drug conjugate (MDC) as a „Trojan horse” approach in cancer therapy

Polish Biochemical Society & L’Oreal for Women in Science Honorary Lecture


Place: S205
Session line
Metabolite World
Cell & Organ World
World of Application / Bioinformatics
9.45-11.15
session 23

Place: S204
session 24

Place: S205
session 25

Place: S207
Joanna Sułkowska
CENT, Warsaw, Poland
Andrzej Joachimiak
Argonne National Laboratory, Argonne, USA

Entanglement in biology - from proteins folding to drug design
Grzegorz Węgrzyn
UG, Gdańsk, Poland
Ewa Bartnik
UW, Warsaw, Poland

Mitochondrial and lysosomal diseases
Cezary Czaplewski
UG, Gdańsk, Poland
Stanisław Ołdziej
IFB UG&MUG, Gdańsk, Poland

From experimental data to in silico simulations and way back

Session sponsored by Openexome
Lectures:Lectures:Lectures:
9.45-10.15
L.23.1. Andrzej Joachimiak
Argonne National Laboratory, Argonne, USA
Targeting allosteric site in drug discovery – a case of tryptophan synthase
L.24.1. Grzegorz Węgrzyn
UG, Gdańsk, Poland
Mechanisms and therapeutic options of lysosomal storage diseases
L.25.1. Pavel Jungwirth
Inst. Organic Chemistry and Biochemistry, ASCz, Prague, Czech Rep.
Cell Penetration and Membrane Fusion: Two Sides of the Same Coin
Lecture Sponsored by the Rector of the University of Gdańsk
10.15-10.45
L.23.2. Ya-Ming Hou
Thomas Jefferson University, Philadelphia, USA
tRNA methylation: a determinant of mitochondrial pathogenesis
L.24.2. Ewa Bartnik
UW, Wrocław, Poland
Leber's hereditary optic neuropathy
L.25.2. Cezary Czaplewski
UG, Gdańsk, Poland
Modeling of protein structure and dynamics with the UNRES force field assisted by limited experimental data and knowledge-based information
10.45-11.00
O.23.1. Rafal Augustyniak
Visualizing supramolecular machines in action by methyl TROSY-NMR - substrate processing by AAA+ unfoldases
O.24.1. Katarzyna Tońska
Nuclear genes involved in mitochondrial diseases with mitochondrial DNA instability in adults
O.25.1. Piotr Setny
Protein hydraulics: water driven substrate binding cooperativity to protein kinase A
11.00-11.15
O.23.2. Agata Perlinska
Characterization of substrate binding and function of a knotted protein
O.24.2. Marta Kaczor-Kamińska
The murine cellular model of mucopolysaccharidosis III, type B (MPS IIIB) – a preliminary study
O.25.2. Stanisław Ołdziej
DNA binding to DnaA replication initiator protein – implications on the structure of the replication initiation complex
11.45-13.15
session 26

Place: S204
session 27

Place: S205
session 28

Place: S207
session 29

Place: S208
Jacek Drobnik
MU, M Łódź, Poland
Aleksander R. Sieroń
SUM Katowice, Poland

Biochemistry of the connective tissue
Jolanta Jura
WBBB UJ, Cracow, Poland
Piotr Widłak
IO Gliwice, Poland

Inflammation and cancer
Hanna Mazur-Marzec
UG, Gdańsk, Poland
Konrad Ocalewicz
UG, Gdańsk, Poland

Marine biotechnology
Janusz Rak
UG, Gdańsk, Poland
Elise Dumont
ENS, Lyon, France

Modeling of radiation damage to DNA
Lectures:Lectures:Lectures:Lectures:
11.45-12.15
L.26.1. Leszek Kaczmarek
Nencki Inst. of Experimental Biology PAS, Poland
Matrix metalloproteinase-9 in the brain: Beyond the connective tissue
L.27.1. Wim Declercq
VIB Center for Inflammation Research IRC, Belgium
RIPK4 maintains epidermal homeostasis and prevents skin cancer by suppressing mitogenic signaling
L.28.1. Hanna Mazur-Marzec
UG, Gdańsk, Poland
Biotechnological potential of Baltic cyanobacteria.
L.29.1. Michael D. Sevilla
Oakland University, MI, USA.
Free radical mechanisms of radiation damage to DNA
12.15-12.30
L.26.2. Aleksander R. Sieroń
SUM, Katowice, Poland
Tolloids, function-structure relations and related disorders resulting from
extra-cellular matrix pathology
O.27.1. Agata Lichawska-Cieslar
Epidermal MCPIP1 function is essential to maintain proper skin homeostasis
L.28.2. Małgorzata Wiweger
IIMCB, Warsaw, Poland
Fish models for biomedical research.
L.29.2. Jorge Kohanoff
Queen's University Belfast, UK
Can low-energy electrons produce DNA strand breaks in the physiological environment?
12.30-12.45
O.27.2. Luiza Handschuh
Levels of NPM1 alternative transcripts in acute myeloid and lymphoblastic leukemia
12.45-12.55
O.26.1. Małgorzata Gałdyszyńska
Collagen metabolism within cardiac fibroblast is modified by physical properties of cell environment
O.27.3. Seweryn Mroczek
The non-canonical poly(A) polymerase FAM46C regulates B-cells proliferation and acts as an onco-suppressor in multiple myeloma
O.28.1. Ewa Piotrowska
Characterization of biological activities of marine cyanobacteria-derived peptides
L.29.3. Elise Dumont
ENS, Lyon, France
Probing the mechanistic pathways and structural aftermaths of complex DNA lesions
12.55-13.00
O.26.2. Monika Dyńda
Effect of the extracellular collagen type I on cardiac fibroblasts
13.00-13.05
O.27.4. Piotr Widłak
(Serum) cancer biomarkers or inflammation biomarkers?
O.28.2. Sławomir Ciesielski
Marine bacteria as potential producers of polyhydroxyalkanoates
13.05-13.15
O.26.3. Jacek Drobnik
Effect of histamine on collagen content in cardiac myofibroblasts culture
13.15-13.20
13.30-14.00
Lunch
and
Poster session: P20-P31

Poster sessions list
14.00-14.45
Closing Lecture
Agnieszka Chacińska
Centre of New Technologies University of Warsaw, Poland

IRAP Warsaw Lecture
Stress management in response to mitochondrial dysfunction


Place: S205
14.45-16.30
Closing Ceremony

Place: S205
Tuesday, 18th September 2018
15.00-17.30
Meeting of the Board of Polish Biochemical Society

Place: D209
18.00-19.30
Opening ceremony
Opening Lectures


Place: S204/205
18.30-19.00
PL.1. Ted Hupp
University of Edinburgh, Scotland, International Centre for Cancer Vaccine Science Gdańsk

Interferon responsive genes that link adaptive and innate immunity in human cancer


Place: S204/205
19.00-19.30
PL.2. Robin Fahraeus
Paris Diderot University, France, International Centre for Cancer Vaccine Science Gdańsk

Viral mRNA translation control: linking immune evasion with oncogenesis


Place: S204/205
19.30
Welcome Party

Place: Upper level of the Faculty of Social Sciences University of Gdańsk
Wednesday, 19th September 2018
Plenary Lecture
Morning sessions
9.00-9.45
PL.3. Marek Figlerowicz
Institute of Bioorganic Chemistry PAS, Poznań, Poland

Genomics in uncovering our history


Place: S205
Session line
DNA World
RNA World
EMBO
Polish Society for Cell Biology
session 1

Place: S204
session 2

Place: S205
session 3

Place: S207
session 4

Place: S208
Morning sessions
9.45-13.15
Marek Figlerowicz
IBCh PAS, Poland
Tomasz Żemojtel
Berlin Inst. of Health, Germany

Genomics and genomics-driven research
Andrzej Dziembowski
IBB & UW, Poland

RNA and RNP structures and mechanisms of action: from theory to experiment

Krzysztof Liberek
IFB UG&MUG, Gdańsk, Poland
Joanna Sułkowska
CENT Poland

EMBO Session

Halina Gabryś
UJ, Cracow, Poland

Signaling in plant cells

Lectures:Lectures:Lectures:Lectures:
09.45-09.50
IBCh PAS, Poland
Tomasz Żemojtel
Berlin Inst. of Health, Germany

Short introduction
L.2.1. Marcin Nowotny
IIMCB, Warsaw, Poland

Structural and biochemical studies of the yeast mitochondrial RNA degradosome
Krzysztof Liberek
IFB UG&MUG, Gdańsk, Poland

Introduction
L.4.1. Ute Vothknecht
Univ. of Bonn, Germany

Calcium Regulation of Plant Organellar Metabolism

09.50-10.00
L.3.1. Magda Konarska
CENT, Warsaw, Poland, new EMBO member

Dynamic rearrangements of the spliceosomal catalytic center
10.00-10.15
L.1.1. Izabela Makałowska
UAM, Poznań, Poland

Activity of retroposed genes in tumors
10.15-10.30
L.2.2. Jacek Jemielity
CENT, Warsaw, Poland

Chemically modified mRNA
L.3.2. Joanna Sułkowska
CENTR, Warsaw, Poland
EMBO Young Investigator

Mysteries of entanglement – from a single protein to a pair of chromosomes

L.4.2. Axel Mithofer
Max-Planck-Inst. for Chemical Ecology, Jena, Germany

Plant Calcium Signaling in biotic Interactions

10.30-10.35
10.35-10.40
L.1.2. Tomasz Żemojtel
Berlin Inst. of Health, Germany

Liquid biopsy: challanges and opportunities
10.40-10.45
L.3.3. Piotr Ziółkowski
UAM, Poznań, Poland
EMBO Installation Ggrantee

Control of meiotic recombination: from chromosomal distribution to crossover frequency
10.45-11.05
L.2.3. Maciej Kozak
UAM, Poznań, Poland

Applications of small-angle X-ray and neutron scattering (SAXS/SANS) in studies of complexes and flexible protein structures
L.4.3. Halina Gabryś
UJ, Cracow, Poland

Calcium and magnesium in blue light signaling in the mesophyll cell

11.05-11.10
Break
11.10-11.15
Break
11.15-11.35
Break
11.35-11.40
Break
L.3.4. Marta Miączyńska
IIMCB, Warsaw, Poland
new EMBO member

Inflammatory signaling from the endocytic pathway

Break
11.40-11.45
L.1.3. Agnieszka Żmieńko

AthCNV - a map of DNA copy number variations in Arabidopsis thaliana genome based on the 1001 Genomes Project data
Break
11.45-12.00
L.2.4. Krzysztof Ginalski
CENT, Warsaw, Poland

Identification and classification of proteins involved in nucleic acids metabolism
L.4.4. Dorota Konopka-Postupolska
IBB, Warsaw, Poland

The role of calcium in cellular membrane flow
12.00-12.15
L.3.5. Maria Górna
UW, Warsaw, Poland
EMBO Installation Grantee

Installation Grantee
How to end a viral RNA- lessons from the IFIT proteins
12.15-12.25
O.1.1. Małgorzata Marcinkowska-Swojak

Half the costs keep the quality. Targeted enrichment for the Next Generation Sequencing of ancient genomes
L.2.5. Andrzej Dziembowski
CENTIBB & UW, Warsaw, Poland

Regulation of gene expression by non-canonical poly(A) and poly(U) polymerases
O.4.1.Małgorzata Pietrowska-Borek

Is RAB GTPase homolog E1B (RABE1b) involved in response to cadmium stress in Arabidopsis thaliana seedlings by cGMP synthesis?
12.25-12.30
L.3.6. Wojciech Pokrzywa
IIMCB, Warsaw, Poland
EMBO Installation grantee

Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
12.30-12.45
O.1.2. Patrycja Jakubek

Catechins as modulators of DNA methylation
O.4.2. Weronika Krzeszowiec-Jeleń

Exogenous amino acids affect the image of actin cytoskeleton in Arabidopsis mesophyll cells
12.45-12.50
O.1.3. Sabina Żołędowska

Investigating the pangenome of the plant pathogenic Pectobacterium parmentieri provides insight into its outstanding adaptation abilities
O.2.1. Roman Szczęsny

The mitochondrial degradosome complex and its co-factors prevent accumulation of double-stranded RNA in humans
12.50-13.00
L.3.7. Agata L. Starosta

Undercover translation. Hidden secrets of the ribosome
13.00-13.15
O.1.4. Agata Motyka

Closure of the Dickeya solani pangenome
O.2.2. Michał Wojciech Szcześniak

Long non-coding RNAs as modulators of
splicing in trans via direct RNA:RNA interactions
13.30-14.15
Lunch
and
Poster session: P1-P8

Poster sessions list
14.30-15.15
PL.4. Bożena Kamińska-Kaczmarek
Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

Immune microenvironment of glioma

Lecture sponsored by Nencki Inst. of Experimental Biology PAS, Warsaw, Poland- 100 years anniversary of the Nencki Inst. of Experimental Biology PAS


Place: S205
Session line
New molecular targets / World of application
RNA World
Protein World
Session sponsored by COST Action CA16112 "NutRedOx"
session 5

Place: S204
session 6

Place: S205
session 7

Place: S207
session 8

Place: S208
session 30

Place: S211
Afternoon sessions
15.15-16.45
Krystyna Bieńkowska-Szewczyk
IFB UG&MUG, Gdańsk, Poland
Bogusław Szewczyk
UG&MUG

Molecular virology
Zofia Szweykowska-Kulińska
UAM, Poznań, Poland
Piotr Kozłowski
IBCh PAS, Poznań, Poland


Non-coding RNA and gene expression

Marcin Nowotny
IIMCB, Warsaw, Poland
Alessandro Costa
The Francis Crick Inst., London, UK

Structural studies of large assemblie


Adam Szewczyk
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland
Wiesława Jarmuszkiewicz
UAM, Poznań, Poland

Molecular bioenergetics
Caroline Gaucher
University of Lorraine, Nancy, France
Jędrzej Antosiewicz
MUG, Gdańsk, Poland

Redox control of major age-related diseases
Lectures:Lectures:Lectures:Lectures:Lectures:
15.15-15.25
L.5.1. Timm C. Harder
FLI, Riems, Germany

100 years from Spanish flu- can we control influenza today?
Zofia Szweykowska-Kulińska
UAM, Poznań, Poland
Piotr Kozłowski
IBCh PAS, Poznań, Poland
Marek Figlerowicz
Institute of Bioorganic Chemistry PAS, Poznań, Poland

Introduction

In memory of Professor Włodzimierz Krzyżosiak
L.7.1. Wojciech Galej
EMBL, Grenoble, France

Structure and dynamics of the spliceosome
L.8.1. Wiesława Jarmuszkiewicz
UAM, Poland

Impact of temperature and training on skeletal muscle bioenergetics

L.30.1. Marc Diederich
Seoul National University, Korea

About canonical and less canonical cell death induction by natural compounds with pharmacological potential
15.25-15.45
L.6.1. Zofia Szweykowska-Kulińska
UAM, Poland

Biogenesis and function of plant microRNAs
15.45-16.05
L.5.2. Arvind H. Patel
MRC-University of Glasgow Centre for Virus Research, UK

Conformational flexibility in the receptor-binding
site of the Hepatitis C Virus Glycoprotein E2

100 years from Spanish flu- can we control influenza today?
L.6.2. Piotr Kozłowski
IBCh PAS, Poznań, Poland

Copy number variation and other types of genetic alterations in miRNA genes and their potential implications for miRNA function and human diseases
L.7.2. Alessandro Costa
The Francis Crick Institute, London, UK

Eukaryotic replisome assembly and fork progression visualized by cryo-EM
L.8.2. Wiesław Gruszecki
UMCS, Lublin, Poland

Warming-up of the chloroplast

L.30.2. Marek Naruszewicz
Medical University of Warsaw, Poland

Oleacein, translation from Mediterranean diet to preventive medicine
16.05-16.15
O.6.1. Susheel Sagar Bhat

Arabidopsis thaliana mRNA adenosine methylase (MTA) is an important player in miRNA biogenesis regulatory pathway
16.15-16.25
L.5.3. Alicja Chmielewska

Adenovirus vectors for genetic vaccination and oncolytic virotherapy
O.6.2. Anna Kurzyńska-Kokorniak

A possible direct involvement of Dicer ribonuclease in the post-transcriptional control of gene expression
L.7.3.Michał Szymański
IFB UG & GUMed, Gdańsk, Poland

Structure and function of macromolecular machines
L.8.3. Adam Szewczyk
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland

Mitochondrial regulation of mitochondrial potassium channels

L.30.3. Tomris Ozben

Natural redox modulators of oxidative stress and chemoresistance in cancer therapy: beneficial versus deleterious effects
16.25-16.35
O.6.3. Joanna Boguslawska

TGF-β1 affects proliferation, viability and migration of renal cancer cells, possibly by targeting regulatory microRNAs
16.35-16.45
O.6.4. Ankur Gadgil

U7 snRNA activity and histone gene expression is affected by ALS-linked FUS mutations
16.45-17.00
BreakBreak
17.00-18.00
Sponsored session

Place: S205
O.8.1. Bogusz Kulawiak

Single-channel properties of the ROMK2-pore-forming subunit of the mitochondrial ATP-regulated potassium channel

17.00-17.15
Merck sponsored session

Immunophenotyping Extracellular Vesicles using innovative flow cytometry
17.15-17.30
O.7.1. Michał Gabruk

Towards the near-atomic resolution structure of light-dependent protochlorophyllide oxidoreductase
O.8.2. Andonis Karachitos

Evaluation of mitochondrial energetic status and oxidative stress during tardigrade anhydrobiosis
17.30-17.45
O.8.3. Karol Parchem

Dietary oxidized phospholipids: digestion, absorption and metabolism
17.45-17.55
O.8.4. Karolina Dominiak

Coenzyme Q and ROS production in mitochondria
17.55-18.00
18.00-19.30
General assembly of the Polish Biochemical Society

Place: S205
Thursday, 20th September 2018
Plenary Lecture
Morning session
9.00-9.45
PL.5. Peter Mackenzie
Flinders University, Adelaide, Australia
The UDP glycosyltransferase superfamily: its role in signal transduction termination and protection against chemical toxicity

Lecture sponsored by the Rector of the Gdańsk University of Technology


Place: S205
Session line
Metabolite World
Cell & Organ World
DNA World
Sesion sponsored by COST Action CA16112 "NutRedOx"
9.45-11.15
session 9

Place: S204
session 10

Place: S205
session 11 - part I

Place: S207
session 12

Place: S208
session 30 part II

Place: S211
Władysława A. Daniel
PAS, Poland
Krzysztof Safranow
PUM, Szczecin, Poland

The physiological and pharmacological regulation of endobiotic and drug metabolizing enzymes

Ryszard T. Smoleński
MUG, Gdańsk, Poland
Stefan Chłopicki
UJ, Cracow, Poland

Endothelial dysfunction and atherosclerosis
Agnieszka Łoboda
UJ, Cracow, Poland
Robert Passier
University of Twente, Enschede, The Netherlands

Medical biotechnology in regenerative medicine and drug research

Session sponsored by STARBIOS 2 Structural Transformation to Attain Responsible BIOSciences EU FP Horizon 2020
Jarosław Marszałek
IFB UG&MUG, Gdańsk, Poland
Ryszard Korona
UJ, Cracow, Poland

Evolutionary biochemistry
Agnieszka Bartoszek
Gdańsk University of Technology, Gdańsk
Mustafa C. Malki
Université de Bourgogne, Dijon, France

Redox control of major age-related diseases
Lectures:Lectures:Lectures:Lectures:Lectures:
09.45-10.15
L.9.1. Władysława A. Daniel
PAS, Poland

The regulation of liver cytochrome P450 by the brain nervous system

L.10.1. Ryszard T. Smoleński
MUG, Gdańsk, Poland

Energetics of cardiac myocyte in atherosclerosis
L.11.1. Graziella Pellegrini
Univ. of Modena, Italy

Epithelial stem cells, a real tool for effective regenerative medicine treatments

L.12.1. Grzegorz Kudła
Univ. of Edinburgh, UK

Next generation genotype-phenotype mapping
L.30.4. Linda Giblin

Whey Protein: can it boost cellular antioxidant processes?

10.15-10.45
L.9.2. Krzysztof Safranow
PUM, Szczecin, Poland

Consequences of muscle AMP deaminase deficiency caused by common nonsense mutation In AMPD1 gene – a new look at the role of purine nucleotide cycle

L.10.2. Stefan Chłopicki
UJ, Cracow, Poland

Endothelial profiling in vivo: novel approach to experimental pharmacology of endothelium
L.11.2. Józef Dulak
UJ, Cracow, Poland

Targeting inflammation for treatment of Duchenne muscular dystrophy

L.12.2. Kataryna Tomala
UJ, Cracow, Poland

Searching for factors underlaying slower evolution of abundant proteins
L.30.5. Jarosław Paluszczak

Modulation of Wnt signaling by natural and synthetic compounds in cancer cells
10.45-11.00
O.9.1. Agnieszka Potęga

Electrochemistry/liquid chromatography/mass spectrometry for the simulation of in vitro metabolism of unsymmetrical bis-acridines with antitumor properties

O.10.1. Alicja Bulińska

Nucleotide and adenosine converting ecto-enzyme pattern in endothelial activation and vascular inflammation

O.11.1. Krzysztof Kobielak

Regulation of hair follicle stem cells homeostasis by activation of gene inhibitory network

L.12.3. Ryszard Korona
UJ, Cracow, Poland

The paradox of dominance: halving the dose of a gene leaves its function unaffected (usually)
11.00-11.15
O.10.2. Armen Trchounian

Antioxidant activity of alcohol extracts from some plants of Armenian flora: the highest level and its possible nature

O.11.2. Jacek Stępniewski

Administration of HO-1/SDF-1α-overexpressing mesenchymal stromal cells in murine and swine model of myocardial infarction and heart failure – analysis of therapeutic effect

11.15-11.45
Break
Session line
Metabolite World
Cell & Organ World
New molecular targets / World of application
11.45-13.15
session 13

Place: S204
session 14

Place: S205
session 11 - part II

Place: S207
session 15

Place: S208
Wanda Baer-Dubowska
PUMS, Poland
Gniewomir Latacz
UJ, Cracow, Poland

Metabolic activation of xenobiotics - therapeutic target and drug monitoring
Anna Ronowska
Medical University of Gdańsk, Poland
Andrzej Szutowicz
Medical University of Gdańsk, Poland

New biomarkers in neurodegenerative diseases
Józef Dulak
UJ, Cracow, Poland
Graziella Pellegrini
University of Modena, Modena, Italy

Medical biotechnology in regenerative medicine and drug research

Session sponsored by STARBIOS 2 Structural Transformation to Attain Responsible BIOSciences EU FP Horizon 2020
Tomasz Wilanowski
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland
Anna Radominska-Pandya
University of Arkansas of Medical Sciences , USA

New molecular targets in personalized therapy of cancer

Lectures:Lectures:Lectures:Lectures:
11.45-12.15
L.13.1. Uwe Sauer
Inst. of Molecular Systems Biology, Switzerland

Metabolic coordination through metabolite-protein interactions

L14.1. Monika Szeliga-Mossakowski
Medical Research Centre PAS, Warsaw, Poland

Astroglia in health and pathology

L.11.3. Robert Passier
Univ. of Twente, The Netherlands

Human pluripotent stem cell-derived cardiac cells for disease modeling, drug screening and regenerative medicine

L.15.1. Tomas Wilanowski
Nencki Inst. of Experimental Biology PAS, Warsaw, Poland

Grainyhead-like transcription factors as targets of anti-cancer therapy
12.15-12.45
L.13.2. Hanna Piotrowska-Kempisty
PUMS, Poland

The metabolic activation of methylated resveratrol analogue 3,4,4’,5-tetra-methoxystilbene (DMU-212) to 3’hydroxy-3,4,4,4’-tetramethoxystilbene (DMU-214)
L.14.2. Andrzej Szutowicz
MUG, Gdańsk, Poland

Regulatory effects of acetyl-CoA distribution in cellular compartments of healthy and diseased brain

L.11.4. Agnieszka Łoboda
UJ, Cracow, Poland

HO-1 as a possible drug target

L.15.2. Anna Radominska-Pandya
UAMS, USA

Natural Compounds Activating Cannabinoid Receptors CB1 and CB2: future for the cancer treatments
12.45-12.55
O.13.1. Mikhail Kurbat

Hyperhomocysteinemia caused by highly active antiretroviral therapy (HAART) of HIV infection: focus on mitochondria

O.14.1. Anna Ronowska

Thiamine deficits aggravate zinc cytotoxicity in cholinergic SN56 neuronal cells

O.11.3. Katarzyna Kaławaj

Alpha-ketoglutarate (AKG) induces apoptosis in osteosarcoma cells in vitro through the activation of JNK MAP kinase

O.15.1. Małgorzata Rogalińska

The importance of drug type and dose on CLL cells in vitro sensitivity to anticancer-agents

12.55-13.00
O.15.2. Łukasz Skalniak

Novel strategies of PD-1/PD-L1 immune checkpoint blockade for cancer therapy: antibodies, peptides and small molecule

13.00-13.05
O.13.2. Annamaria Lubelska

Metabolic stability as a challenge in the early stage of drug discovery process – in vitro determination of metabolic pathways for new promising 5-HT7R ligands

O.11.4. Izabela Sadowska-Bartosz

3-Bromopyruvic acid: a small molecule with strong anti-tumor potency

13.05-13.15
O.15.3. Błażej Rubiś

Telomerase targeting modulates cancer response to therapy

13.30-14.15
Lunch
and
Poster session: P11-P19

Poster sessions list
14.30-15.15
PL.6. Narayanan Veeraraghavan
Rady Children’s Hospital-San Diego, USA

Clinical Utility of Rapid Whole Genome Sequencing in pediatric critical care

Lecture sponsored by Rector of the Medical University of Gdańsk


Place: S205
Session line
Metabolite World
Cell & Organ World
New molecular targets / World of application
Satellite session: Women in Science
15.15-16.45
session 16

Place: S204
session 17

Place: S205
session 18

Place: S207
session 19

Place: S208
Satellite session 1

Place: S211
Micał Markuszewski
MUG, Gdańsk, Poland
Micał Ciborowski
Medical University of Bialystok

Clinical metabolomics
Rafał Sądej
IFB UG&MUG, Poland
Anna Żaczek
IFB UG&MUG, Poland

Tumor microenvironment in cancer progression
Piotr Trzonkowski
MUG, Poland
Ewa M. Martinez-Caceres
Generalitat de Catalunya, Spain

New molecular targets
in personalized therapy of autoimmune diseases

Session sponsoring by - COST project - Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies BM1305, EU FP Horizon 2020.
Hanna Jańska
UWr, Wrocław, Poland
Agnieszka Mostowska
UW, Warsaw, Poland

Inside plant organelles: structure, function and stress response
Session sponsored by L’Oreal Poland

Chairwoman - Agnieszka Chacińska
Centre of New Technologies University of Warsaw, Poland
Lectures:Lectures: Lectures:Lectures:Lectures:
15.15-15.45
L.16.1. Danuta Dudzik
San Pablo CEU University, Madrid, Spain

Metabolomics meets clinics - application to maternal-fetal and neonatal medicine
L.17.1. Przemysław Juszczyński
IHiTM, Poland
Tumor suppressor function of FOXO1 in diffuse large B-cell lymphomas: mechanisms of regulation and rational targeting strategies
Parnas Memory Lecture

L.18.1. Ewa M. Martinez-Caceres
Generalitat de Catalunya, Spain

Tolerance-induction with autologous tolerogenic dendritic cells treated with VITamin D3 and loaded with myelin peptides in MultiPe Sclerosis (Tolervit-MS)
L.19.1. Oliver van Aken
Lund Univ., Sweden

Exploring organelle-to-nuclear signaling during plant stress responses.

Annie Black
Deputy Executive Director L'Oréal Corporate Foundation, France Introduction


Agnieszka Chacińska
Centre of New Technologies University of Warsaw, Poland


Panelists:

Bożena Kamińska
Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

Agata Starosta
Maria Curie Skłodowska University in Lublin, Poland

Joanna Sułkowska
Centre of New Technologies University of Warsaw, Poland

Zofia Szweykowska-Kulińska
Adam Mickiewicz University Poznań, Poland
15.45-16.15
L.16.2. Michał Ciborowski
Medical University of Bialystok, Poland

Metabolomics in the clinical settings. Applications in diabetology and endocrinology

L.17.2. Katarzyna Miękus
UJ, Cracow, Poland

Role of anti-inflammatory protein MCPIP1 in clear cell renal cell carcinoma progression

L.18.2. Piotr Trzonkowski
MUG, Gdańsk, Poland

T-regulatory cells to treat autoimmune diseases
L.19.2. Łucja Kowalewska
UW, Warsaw, Poland

Structural plasticity of the chloroplast thylakoid network.

16.15-16.45
L.17.3. Rafał Sądej
IFB UG&MUG, Gdańsk, Poland

Tumour microenvironment in luminal breast cancer progression
L.19.3. Małgorzata Heidorn-Czarna
UW, Warsaw, Poland

Functional relevance of mitoproteases in plant mitochondria.

16.45-17.00
Break
17.00-18.30
session 20

Place: S204
session 17 continued

Place: S205
session 21

Place: S207
session 22

Place: S208
Ewa Świeżewska
IBB, Warsaw, Poland
Anna Ihnatowicz
IFB UG&MUG, Gdańsk, Poland

Plant biochemistry and metabolomics

Rafał Sądej
IFB UG&MUG, Poland
Anna Żaczek
IFB UG&MUG, Poland

Tumor microenvironment in cancer progression
Marta Olejniczak
IBCh PAS, Poznań, Poland
Krzysztof Chyliński
CRISPR Lab, Wien, Austria

CRISPR technologies for targeted genome editing
Dariusz Rakus
UWr, Wrocław, Poland
Jacek R. Wiśniewski
MPI Biochemie, Germany

Proteomics of ageing and diseases
Lectures:Oral presentationsLectures:Lectures:
17.00-17.20
L.20.1. Asaph Aharoni
Weizmann Inst., Israel

Plant ‘Metabolic Caravans’: from anti-nutritional to anti-Parkinson alkaloids

O.17.1. Halina Waś

Chemotherapeutics-treated cancer cells display stem-like and senescent cell feature

L.21.1. Krzysztof Chyliński
CRISPR Lab Vienna, Austria

Temporal control of CRISPR/Cas9 activity
L.22.1. Jacek R. Wiśniewski
MPI Biochemie, Germany

Large scale proteomics for studying physiology and disease

17.20-17.30
17.30-17.40
L.20.2. Anna Ihnatowicz
IFB UG&MUG, Gdańsk, Poland

Genetic regulation of isoprenoid accumulation in plants – what have we learned from analysis of biochemical and genetic data?

L.21.2. Marta Olejniczak
IBCh PAS, Poznań, Poland

Evaluation of CRISPR/Cas9-mediated genome editing efficiency
L.22.2. Aneta Stachowicz

Proteomics of plasma fibrin clot in antiphospholipid syndrome

17.40-17.55
O.17.2. Natalia Bednarz-Knoll

Preoperative high platelets counts and low hemoglobin correlate to mesenchymal phenotype of circulating tumor cells and worse clinical outcome in human breast carcinoma

17.55-18.00
O.17.3. Aleksandra Solecka

The influence of metabolism on the phenotype of astrocytoma U-251 MG cell line

18.00-18.10
O.20.1. Joanna Grzyb

Bionanohybrids between phycobilisomes and colloidal quantum dots – studies of energy transfer in complicated systems

L.22.3. Dariusz Rakus
UWr, Wrocław, Poland

Aging-associated changes in hippocampal glycogen metabolism. Evidence for and against astrocyte-neuron lactate shuttle

18.10-18.15
O.17.4. Izabela Papiewska-Pająk

Extracellular vesicles secreted by colorectal cancer cell line HT29 overexpressing Snail can fuse with and activate the cells constituting metastatic niche

18.15-18.25
O.20.2. Katarzyna Jasieniecka-Gazarkiewicz

Acyl-CoA:lysophosphatidylethanolamine acyltransferase (LPEAT) activity regulates plant growth and autophagy level

18.25-18.30
O.17.5. Magdalena Mizerska-Kowalska

Tumor-associated neutral endopeptidase (tNEP) regulates cell proliferation and TGF-β production in cultures and co-cultures of colon cancer cells with colon fibroblasts

18.30-18.40
20.00
Gala Dinner including complimentary lecture

Place: UNICORN Restaurant
Friday, 21st September 2018
Plenary lecture
9.00-9.45
PL.7. Magdalena Król
SGGW, Warsaw, Poland

The macrophage-drug conjugate (MDC) as a „Trojan horse” approach in cancer therapy

Polish Biochemical Society & L’Oreal for Women in Science Honorary Lecture


Place: S205
Session line
Metabolite World
Cell & Organ World
World of Application / Bioinformatics
9.45-11.15
session 23

Place: S204
session 24

Place: S205
session 25

Place: S207
Joanna Sułkowska
CENT, Warsaw, Poland
Andrzej Joachimiak
Argonne National Laboratory, Argonne, USA

Entanglement in biology - from proteins folding to drug design
Grzegorz Węgrzyn
UG, Gdańsk, Poland
Ewa Bartnik
UW, Warsaw, Poland

Mitochondrial and lysosomal diseases
Cezary Czaplewski
UG, Gdańsk, Poland
Stanisław Ołdziej
IFB UG&MUG, Gdańsk, Poland

From experimental data to in silico simulations and way back

Session sponsored by Openexome
Lectures:Lectures:Lectures:
9.45-10.15
L.23.1. Andrzej Joachimiak
Argonne National Laboratory, Argonne, USA
Targeting allosteric site in drug discovery – a case of tryptophan synthase
L.24.1. Grzegorz Węgrzyn
UG, Gdańsk, Poland
Mechanisms and therapeutic options of lysosomal storage diseases
L.25.1. Pavel Jungwirth
Inst. Organic Chemistry and Biochemistry, ASCz, Prague, Czech Rep.
Cell Penetration and Membrane Fusion: Two Sides of the Same Coin
Lecture Sponsored by the Rector of the University of Gdańsk
10.15-10.45
L.23.2. Ya-Ming Hou
Thomas Jefferson University, Philadelphia, USA
tRNA methylation: a determinant of mitochondrial pathogenesis
L.24.2. Ewa Bartnik
UW, Wrocław, Poland
Leber's hereditary optic neuropathy
L.25.2. Cezary Czaplewski
UG, Gdańsk, Poland
Modeling of protein structure and dynamics with the UNRES force field assisted by limited experimental data and knowledge-based information
10.45-11.00
O.23.1. Rafal Augustyniak
Visualizing supramolecular machines in action by methyl TROSY-NMR - substrate processing by AAA+ unfoldases
O.24.1. Katarzyna Tońska
Nuclear genes involved in mitochondrial diseases with mitochondrial DNA instability in adults
O.25.1. Piotr Setny
Protein hydraulics: water driven substrate binding cooperativity to protein kinase A
11.00-11.15
O.23.2. Agata Perlinska
Characterization of substrate binding and function of a knotted protein
O.24.2. Marta Kaczor-Kamińska
The murine cellular model of mucopolysaccharidosis III, type B (MPS IIIB) – a preliminary study
O.25.2. Stanisław Ołdziej
DNA binding to DnaA replication initiator protein – implications on the structure of the replication initiation complex
11.45-13.15
session 26

Place: S204
session 27

Place: S205
session 28

Place: S207
session 29

Place: S208
Jacek Drobnik
MU, M Łódź, Poland
Aleksander R. Sieroń
SUM Katowice, Poland

Biochemistry of the connective tissue
Jolanta Jura
WBBB UJ, Cracow, Poland
Piotr Widłak
IO Gliwice, Poland

Inflammation and cancer
Hanna Mazur-Marzec
UG, Gdańsk, Poland
Konrad Ocalewicz
UG, Gdańsk, Poland

Marine biotechnology
Janusz Rak
UG, Gdańsk, Poland
Elise Dumont
ENS, Lyon, France

Modeling of radiation damage to DNA
Lectures:Lectures:Lectures:Lectures:
11.45-12.15
L.26.1. Leszek Kaczmarek
Nencki Inst. of Experimental Biology PAS, Poland
Matrix metalloproteinase-9 in the brain: Beyond the connective tissue
L.27.1. Wim Declercq
VIB Center for Inflammation Research IRC, Belgium
RIPK4 maintains epidermal homeostasis and prevents skin cancer by suppressing mitogenic signaling
L.28.1. Hanna Mazur-Marzec
UG, Gdańsk, Poland
Biotechnological potential of Baltic cyanobacteria.
L.29.1. Michael D. Sevilla
Oakland University, MI, USA.
Free radical mechanisms of radiation damage to DNA
12.15-12.30
L.26.2. Aleksander R. Sieroń
SUM, Katowice, Poland
Tolloids, function-structure relations and related disorders resulting from
extra-cellular matrix pathology
O.27.1. Agata Lichawska-Cieslar
Epidermal MCPIP1 function is essential to maintain proper skin homeostasis
L.28.2. Małgorzata Wiweger
IIMCB, Warsaw, Poland
Fish models for biomedical research.
L.29.2. Jorge Kohanoff
Queen's University Belfast, UK
Can low-energy electrons produce DNA strand breaks in the physiological environment?
12.30-12.45
O.27.2. Luiza Handschuh
Levels of NPM1 alternative transcripts in acute myeloid and lymphoblastic leukemia
12.45-12.55
O.26.1. Małgorzata Gałdyszyńska
Collagen metabolism within cardiac fibroblast is modified by physical properties of cell environment
O.27.3. Seweryn Mroczek
The non-canonical poly(A) polymerase FAM46C regulates B-cells proliferation and acts as an onco-suppressor in multiple myeloma
O.28.1. Ewa Piotrowska
Characterization of biological activities of marine cyanobacteria-derived peptides
L.29.3. Elise Dumont
ENS, Lyon, France
Probing the mechanistic pathways and structural aftermaths of complex DNA lesions
12.55-13.00
O.26.2. Monika Dyńda
Effect of the extracellular collagen type I on cardiac fibroblasts
13.00-13.05
O.27.4. Piotr Widłak
(Serum) cancer biomarkers or inflammation biomarkers?
O.28.2. Sławomir Ciesielski
Marine bacteria as potential producers of polyhydroxyalkanoates
13.05-13.15
O.26.3. Jacek Drobnik
Effect of histamine on collagen content in cardiac myofibroblasts culture
13.15-13.20
13.30-14.00
Lunch
and
Poster session: P20-P31

Poster sessions list
14.00-14.45
Closing Lecture
Agnieszka Chacińska
Centre of New Technologies University of Warsaw, Poland

IRAP Warsaw Lecture
Stress management in response to mitochondrial dysfunction


Place: S205
14.45-16.30
Closing Ceremony

Place: S205

(The 3rd Congress of Polish Biosciences "BIO 2018 - Through interdisciplinary approach into new solutions” and 51st Meeting of the Polish Biochemical Society Gdańsk (Poland), 18-21 September 2018) - zadanie finansowane w ramach umowy 504/P-DUN/2018 ze środków Ministra Nauki i Szkolnictwa Wyższego przeznaczonych na działalność upowszechniającą naukę.